Lipid nanoparticle (LNP) engineering
Solutions for assembly, stability, tropism, functionalization & more
Context
Lipid Nanoparticles (LNPs) for RNA delivery
Lipid nanoparticles (LNPs) have emerged as a powerful delivery platform for RNA therapies. Their effectiveness hinges on precise design and formulation, which dictate critical biophysical properties such as stability, biodistribution, and cellular uptake. However, optimizing LNPs for therapeutic success requires addressing key challenges such as:
Key Solutions for LNP Engineering
At Aganitha, our LNP engineering solutions integrate high-throughput machine learning and molecular dynamics to accelerate the discovery of ionizable lipids, ensuring maximum LNP payload delivery and stability. We leverage molecular modeling to optimize internal architecture and critical quality attributes, providing deep molecular insights for targeted RNA delivery.
Solution area
Ionizable Lipid Design
Our platform leverages high-throughput machine learning and molecular dynamics to accelerate the discovery of ionizable lipids, ensuring maximum LNP payload delivery, enhanced stability, and minimal toxicity.
Solution area
RNA encapsulation and structural characterization
At Aganitha, we utilize high-resolution molecular dynamics and thermodynamic modeling to optimize LNP internal architecture, ensuring strategically stabilized RNA delivery and protection.
Solution area
LNP structure and internal morphology
We employ atomistic and coarse-grained Molecular Dynamics to reveal LNP internal architecture, providing deep molecular insights into nanoparticle stability and dynamic evolution for optimized delivery.
Solution area
LNP size and polydispersity
Our machine learning framework predicts LNP critical quality attributes, optimizing formulation and process parameters to achieve target particle size, uniform polydispersity, and maximum therapeutic bioavailability.
Solution area
Surface functionalization with mAbs/peptides
At Aganitha, we apply molecular dynamics and ML to engineer targeted LNPs, optimizing surface conjugation of mAbs and peptides for precise cell/tissue-specific delivery, ligand accessibility, and bioactivity.